Oxidant-Antioxidant balance in patients with coronary slow flow.

Sadettin Selçuk Baysal,Şahbender Koç

doi:10.12669/pjms.35.3.162

Abstract

Objective:Recent studies have focused on the probable role of oxidative stress in cardiovascular diseases. We aimed to assess the oxidant/antioxidant biomarkers in coronary slow flow (CSF).Methods:The study included 51 subjects with CSF and age and sex matched 32 controls. Detailed anamnesis of the patients in the study was taken and routine physical examinations were performed. Routine biochemical blood tests were analyzed. Total oxidative status (TOS), oxidative stress index (OSI) and lipid hydroxyperoxide (LOOH) levels as oxidant biomarkers; paraoxonase (PON1), ceruloplasmin (CP), free sulphydryl (SH) groups, and total antioxidant capacity (TAS) levels as antioxidant biomarkers were studied.Results:Baseline demographic characteristics of the study population did not differ significantly between groups.TOS, OSI and LOOH concentrations were higher in study group than in control group. However, there was no significant difference detected in levels of TAS, PON1, SH and CP. Multivariate logistic regression analysis revealed that TOS, hsCRP and smoking were indepedent risk factors of CSF.Conclusions:Although there was not any significant difference in antioxidant biomarkers (TAS, PON1, SH and CP) in CSF patients, we detected increased TOS, OSI and LOOH levels which have oxidant properties. These data supported the possible involvement of oxidative stress in pathogenesis of CSF as previous studies reported.

Highlights

Coronary slow flow (CSF) phenomenon is the slow movement of contrast to distal vascular structures during coronary angiography in patients with normal or near normal epicardial coronary arteries.[1]
Clinical and laboratovary data of case and control groups were similar except high-sensitivity C-reactive protein (p
Total oxidative status (TOS), oxidative stress index (OSI) and LOOH concentrations that reflect oxidative stress were significantly increased in CSF group

Summary

Introduction

Coronary slow flow (CSF) phenomenon is the slow movement of contrast to distal vascular structures during coronary angiography in patients with normal or near normal epicardial coronary arteries.[1]. Free radicals are molecules that contain at least one unconjugated electron in their outer orbit, and are prone to react with other molecules to pair the unstable and single electron. Free radicals make pathological changes in cell membranes, cell. Particles that prevent or delay the effects of the molecules that may lead the oxidation of structural particles in the organism are defined as antioxidants. The imbalance between oxidants and antioxidants causes extremely formation of reactive oxygen species and oxidative damage. This is referred to as oxidative stress.[3,4] Oxidative stress is thought to take part in the etiopathogenesis of many systemic diseases, including cardiovascular diseases.[5,6]

Methods

Results

Conclusion