Abstract
This review examines the role that oxidative stress (OS), and protein oxidation in particular, plays in nutrition, metabolism, and health of farm animals. The route by which redox homeostasis is involved in some important physiological functions and the implications of the impairment of oxidative status on animal health and diseases is also examined. Proteins have various and, at the same time, unique biological functions and their oxidation can result in structural changes and various functional modifications. Protein oxidation seems to be involved in pathological conditions, such as respiratory diseases and parasitic infection; however, some studies also suggest that protein oxidation plays a crucial role in the regulation of important physiological functions, such as reproduction, nutrition, metabolism, lactation, gut health, and neonatal physiology. As the characterization of the mechanisms by which OS may influence metabolism and health is attracting considerable scientific interest, the aim of this review is to present veterinary scientists and clinicians with various aspects of oxidative damage to proteins.
Highlights
In aerobic organisms, mitochondrial and cytochrome P450 metabolism, inflammation processes and several environmental factors are endogenous sources of reactive oxygen species (ROS) [1]
For a better understanding of the role of oxidative stress (OS) and protein oxidation in veterinary medicine, future studies should identify a panel of biomarker of protein oxidation to be used in veterinary medicine
While an OS biomarker should meet a number of criteria (Table 2), it is clear that each biomarker of protein oxidation has its benefits and shortcomings
Summary
This review examines the role that oxidative stress (OS), and protein oxidation in particular, plays in nutrition, metabolism, and health of farm animals. The route by which redox homeostasis is involved in some important physiological functions and the implications of the impairment of oxidative status on animal health and diseases is examined. Protein oxidation seems to be involved in pathological conditions, such as respiratory diseases and parasitic infection; some studies suggest that protein oxidation plays a crucial role in the regulation of important physiological functions, such as reproduction, nutrition, metabolism, lactation, gut health, and neonatal physiology. As the characterization of the mechanisms by which OS may influence metabolism and health is attracting considerable scientific interest, the aim of this review is to present veterinary scientists and clinicians with various aspects of oxidative damage to proteins
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