Abstract
This paper presents experiments carried out to assess physicochemical characteristics of oxaliplatin (OXPt) and to determine its compatibility with the polymeric matrices with most relevance in development of topical drug delivery systems (DDS). Thermal analysis (DSC and DTG) associated with molecular, crystallographic and morphologic (optical microscopy) characterizations of the drug alone or associated with such polymeric matrices was conducted. OXPt could be classified as a class III drug according to BCS, i.e., is highly water soluble but low permeable. OXPt in solid state showed to be adequate for regular pharmaceutical manufacturing conditions, being stable even when exposed to heating and light. Among tested polymers, only chitosan of medium molecular mass showed to be incompatible with OXPt, with strong evidence of chemical decomposition and physical changes in drug-polymer samples. Low molecular mass chitosan, poloxamer 407 and polylactic-co-glycolic acid (PLGA) may be indicated for the development of innovative topical DDS.
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