Abstract
Previous studies of renal oxalate handling have demonstrated that oxalate can be transported by a number of anion transport systems within the kidney including the SO4 2-/oxalate exchanger on basolateral (abluminal) and apical (luminal) membranes1, 2 and the Cl/oxalate exchanger on apical membranes3, 4. These studies demonstrated that pathway(s) exist for transcellular oxalate flux, but technical limitations with studies on membrane vesicles (limited timecourse for transport due to the small intravesicular volumes) and with micropuncture studies (limited control of the composition of the extracellular space) have made it difficult to predict the magnitude or direction of this flux under normal and pathological conditions. Thus the present studies have examined LLC-PK1 cells, a renal epithelial cell line with many characteristics of proximal tubular cells5 as a possible model system for assessing renal oxalate handling.
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