Abstract
IntroductionThe brain-gut axis is implicated in the pathogenesis of Parkinson’s disease (PD). The ‘hibernating spore’ hypothesis proposes that the aetiological agent for PD is a fungal agent or its metabolite...
Highlights
The brain-gut axis is implicated in the pathogenesis of Parkinson’s disease (PD)
This study has shown for the first time that patients seen in tertiary care with refractory IBS during the covid-19 pandemic had a significantly higher symptom burden emphasising the importance of gut-brain axis in IBS
We evaluate the faecal metabolome and mycobiome in PD by assessing volatile organic compounds (VOCs) and highly-conserved fungal rRNA genes, respectively
Summary
The brain-gut axis is implicated in the pathogenesis of Parkinson’s disease (PD). The ‘hibernating spore’ hypothesis proposes that the aetiological agent for PD is a fungal agent or its metabolite – possibly originating from a dysbiosis of the gut mycobiome. Abstracts compared between patients seen in the 12 months before the pandemic (22/03/2019 - 22/03/2020) with those seen in the 12-months after (23/03/2020 - 23/03/2021), using non-parametric tests. Compared to those seen in the 12-months before the pandemic (n=107), the cohort seen during the Covid-19 pandemic (n=83) had a significantly higher median IBS-SSS (318 vs 352, p=0.03), and more extra-intestinal symptoms (noncolonic score: 225 vs 269, p=0.03).
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