Abstract
The effects of prostaglandins (PCs) on ovum transport were investigated in Dutch- belted rabbits. PGF,� or PGE, (5 mg, sc) was administered 4, 9, or 13 h after ovulation (i.e., 14, 19, or 23 h after an injection of 11CC). Animals were sacrificed either 5 or 6 h after treatment, the oviducts removed, divided into three equal segments, and flushed with saline. Neither PCF,� nor PCEgiven at 4 or 9 h after ovulation had an effect on the location of ova when the oviducts were examined 5 h posttreatment. PGF,�, or PGE, treat- ment at 13 h after ovulation resulted in accelerated ovum transport; the majority of ova in prostaglandin-treated animals (35/48 for PGE,; 37/42 for PGF2.,) were found either in the proximal third of the oviduct, the uterus, or were not recovered. Unrecovered ova were assumed to be in the uterus or to have been transported through the reproductive tract. Prostaglandin treatment hastened the arrival of ova at the uterus by approximately 40 h. It is concluded that both PGF:,, and PGE, can accelerate ovum transport in the rabbit, when administered in pharmacologic doses.
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