Abstract
The complete refractoriness of the common frog, Rana pipiens, to mammalian gonadotropic factors has attracted considerable attention, especially from point of view of comparative endocrinology and when considering such concepts as species gonadotropic specificity.1 On the other hand, stimulation of the reproductive tracts of immature mice has been brought about by large doses of fresh anterior pituitary from Rana pipiens.2 For further investigation of this problem the following preliminary experiment was undertaken.Twenty-nine adult female Rana pipiens received abdominal injections, in varying concentrations, of (1) gonadotropic factors of mammalian anterior pituitary, (2) gonadotropic factors of pregnant mare's serum (gonadogen), (3) α-estradiol dipropionate (diovocylin), (4) progesterone (lutocylin), and (5) testosterone propionate (oreton). Injections of distilled water, sesame oil, and homoplastic pituitaries served as controls.Approximately 72 hours after treatment an attempt to strip eggs was perfor...
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