Abstract
Ovulatory Follicular Fluid Facilitates the Full Transformation Process for the Development of High-Grade Serous Carcinoma
Highlights
High-grade serous carcinoma (HGSC) is the most common and lethal subtype of epithelial ovarian cancer
Cumulative evidence has revealed that majority of HGSC originates from the epithelium of the fallopian tube, especially at the fimbria, which directly exposes to the follicular fluid (FF) during ovulation [3,4,5]
E6 and E7 interacted with other cellular proteins [25] and exerted diverse effects, including epigenetics [26]
Summary
High-grade serous carcinoma (HGSC) is the most common and lethal subtype of epithelial ovarian cancer. Breast cancer (BRCA1/2) gene carriers who underwent prophylactic salpingo-oophorectomy were shown to have precursor lesions with TP53 mutation, including p53 signature, serous intraepithelial lesion (STIL), and less commonly, serous tubal intraepithelial carcinoma (STIC) in the fallopian tube epithelium (FTE) [6,7]. These tubal p53 lesions were found in patients with ovarian HGSC who underwent surgery [8] and showed a clonal relationship with concurrent HGSC lesions [9,10,11]. Conclusions: Our data demonstrate an extensive transformation activity of FF in the full journey of carcinogenesis, and endorsed ovulation-inhibition for the prevention and AKT-inhibition for the treatment of ovarian HGSC
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