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Abstract
Oviduct-specific glycoprotein 1 (OVGP1) is implicated in playing a role in fertilization and early embryo development. In this study, we have obtained the sequence of intron 9 of OVGP1 gene in swine. Comparative sequencing of Meishan (a native Chinese breed) and Large White pig breeds revealed an A/T substitution at position 943. A PCR-EcoRI-RFLP assay was developed to detect this mutation. Polymorphism analysis in Qingping animals showed that pigs with BB genotype had lower number of piglets born alive (NBA) in multiple parities than pigs with AA (p<0.05) and AB genotype (p<0.01). In Large White×Meishan (LW×M) F2 offspring, the weight of both ovaries (OW) of the BB genotype was significantly lighter than that of AB (p = 0.05) and AA (p<0.01) genotypes. Analysis of the data also revealed that the mutation locus affected these two traits mostly by additive effects. These studies indicated that the polymorphism was associated with NBA and OW in two distinct populations and further investigations in more purebreds or crossbreds are needed to confirm these results. (Asian-Aust. J. Anim. Sci. 2006. Vol 19, No. 5 : 632-637)
Highlights
Key Laboratory of Pig Genetics and Breeding, Ministry of Agriculture, Huazhong Agricultural University Wuhan 430070, P
All for fertilization, early embryonic development and delivery these researches suggested that Oviduct-specific glycoprotein 1 (OVGP1) might have a role in of a viable embryo to the uterus (Boatman et al, 1997). the early reproductive events occurring within the oviduct
The purpose of our research was to perovulatory phase of the menstrual cycle and several determine whether the single nucleotide polymorphisms investigators indicated that synthesis of the OVGP1 was (SNP) of the ninth intron in porcine OVGP1 gene would be controlled by ovarian steroids
Summary
Key Laboratory of Pig Genetics and Breeding, Ministry of Agriculture, Huazhong Agricultural University Wuhan 430070, P. All for fertilization, early embryonic development and delivery these researches suggested that OVGP1 might have a role in of a viable embryo to the uterus (Boatman et al, 1997). OVGP1 is a high molecular weight glycoprotein belonging Due to the physiological function of OVGP1 during to the chitinase protein family and presented in the oviduct fertilization, OVGP1 is a functional candidate gene for (Agarwal et al, 2002). It is synthesized from the oviductal reproductive traits in mammal. OVGP1 can attach itself to the ovulated oocyte and early embryo during their transit in MATERIALS AND METHODS
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