Abstract
There is limited information on the association of overweight and obesity with cardiac remodeling in elderly population. Therefore, we investigated whether overweight and obesity are associated with cardiac geometric structures and function in Chinese elderly. A total of 1183 hospitalized patients (aged 65–99 years) with primary hypertension were collected retrospectively in a cross-sectional study, and divided into underweight, normal weight, overweight and obesity patient groups according to their body mass index (BMI). Cardiac echocardiographic parameters were compared between the groups. BMI was 17.2 ± 1.2, 21.4 ± 1.2, 25.1 ± 1.2, 30.2 ± 2.6 kg/m2 in underweight, normal weight, overweight and obesity groups respectively. Aortic and left atrial diameter, interventricular septal and left ventricular (LV) posterior wall thickness, LV end-diastolic and end-systolic diameter, and indexed LV mass, and prevalence of E/A reversal were higher, while LV ejection fraction and fractional shortening were lower in elderly with overweight or obesity, as compared with whose with underweight or normal weight separately (All P < 0.05). However, multivariable regression analysis showed that overweight and obesity are independently related to increased LV wall thickness, end-diastolic diameter and mass (All P < 0.05). In conclusions, this study demonstrates that overweight and obesity are associated with increased LV wall thickness, end-diastolic diameter and mass in Asian elderly.
Highlights
There is limited information on the association of overweight and obesity with cardiac remodeling in elderly population
The male sex, body mass index (BMI), prevalence of hypertension, dyslipidemia and type 2 diabetes mellitus (DM), plasma glucose, HbA1c, fatty liver markers, uric acid, cigarette smoking, alcohol drinking, and the use of medications were higher in overweight patients as compared with underweight or normal weight patients (All P < 0.05, Tables 1–2)
The above mentioned parameters have increased in the obese patients as compared with the underweight or normal weight patients, as shown in the Tables 1–2
Summary
There is limited information on the association of overweight and obesity with cardiac remodeling in elderly population. Aortic and left atrial diameter, interventricular septal and left ventricular (LV) posterior wall thickness, LV end-diastolic and end-systolic diameter, and indexed LV mass, and prevalence of E/A reversal were higher, while LV ejection fraction and fractional shortening were lower in elderly with overweight or obesity, as compared with whose with underweight or normal weight separately (All P < 0.05). A study has shown that the mortality is lower in elderly with overweight or mild moderate obesity than whose with normal bodyweight[4], overweight and obese patients usually have comorbidities such as hypertension, type 2 diabetes mellitus and dyslipidemia than whose with normal bodyweight[5,6]. We collected data on Chinese elderly patients with primary hypertension in a cross-sectional study in order to investigate the relationship of overweight and obesity to cardiac remodeling and function
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