Abstract
Gastric cancer is the fifth most common cancer and the third most common cause of cancer death all over the world. E-cadherin encoded by human CDH1 gene plays important roles in tumorigenesis as well as in tumor progression, invasion and metastasis. Full-length E-cadhrin tethered on the cell membrane mainly mediates adherens junctions between cells and is involved in maintaining the normal structure of epithelial tissues. After proteolysis, the extracellular fragment of the full-length E-cadhein is released into the extracellular environment and the blood, which is called soluble E-cadherin (sE-cadherin). sE-cadherin promots invasion and metastasis as a paracrine/autocrine signaling molecule in the progression of various types of cancer including gastric cancer. This review mainly summarizes the dysregulation of E-cadherin and the regulatory roles in the progression, invasion, metastasis, and drug-resistance, as well as its clinical applications in diagnosis, prognosis, and therapeutics of gastric cancer.
Highlights
IntroductionThe incidence and mortality of gastric cancer are much higher than the world average, which seriously affects our health (Sung et al, 2021)
Gastric cancer (GC) is one of the common malignant tumors of the digestive tract
This review mainly summarizes the dysregulation of E-cadherin and the regulatory roles in the progression, invasion, metastasis, and drug-resistance, as well as its clinical applications in diagnosis, prognosis, and therapeutics of gastric cancer
Summary
The incidence and mortality of gastric cancer are much higher than the world average, which seriously affects our health (Sung et al, 2021). Gastric cancer is mostly sporadic, but about 10% of gastric cancers have family clustering characteristics, of which 1/3 are considered to have genetic background. This part of gastric cancer is called hereditary diffuse gastric cancer (HDGC) (Blair et al, 2020). Smoking (Shikata et al, 2008) and alcohol consumption (Deng et al, 2021), eating habits (Takezaki et al, 1999; Kobayashi et al, 2002), chronic atrophic gastritis, and EBV or Helicobacter pylori infection (Arif and Syed, 2007; Holleczek et al, 2020) have been considered the most important risk factors for gastric cancer (FORMAN, 1991)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
