Abstract
Conventional oral dosage forms offer no control over drug delivery, leading to fluctuations in plasma drug level. The floating or hydrodynamically controlled drug delivery systems are useful in such application. Floating microspheres are especially suitable for achieving sustained or delayed release oral formulations with flexibility of blending to attain different release patterns, low risk of dose dumping as well as reproducible and short gastric retention time. The floating microspheres produces controlled delivery of drug and also enhance the bioavailability of drug. Floating microsphere is especially gaining attention due to their wide applicability in the targeting of drugs to the stomach. These floating microspheres have the advantage that they remain buoyant and distributed uniformly over the gastric fluid to avoid the vagaries of gastric emptying retention time of drugs. This review provides an overview of scientific work done in the formulation and development of various drug for floating microspheres.
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