Abstract
Critically ill children are a unique population who frequently receive plasma and platelet transfusions for both active bleeding and mitigation of bleeding risk. While these products are frequently administered, transfusion indications in this population remain unclear, and practice varies across institutions and providers. In this manuscript, we will outline the current evidence regarding plasma and platelet transfusions for hemostasis in the pediatric intensive care setting. For both products, we will describe the product composition, epidemiology, and product indications and discuss the potential risks and benefits involved with the transfusion. We will also discuss knowledge gaps and future areas of research.
Highlights
Overview of Plasma and Platelet Transfusions in Critically Ill ChildrenStacie Kahn 1*†, Madhuradhar Chegondi 2†, Marianne E
Plasma and platelet transfusions are frequently administered to critically ill children to prevent bleeding and help treat active bleeding
Plasma is given to critically ill children for a variety of reasons with the most common being coagulopathy, bleeding, and prevention of bleeding in those preparing for an invasive procedure
Summary
Stacie Kahn 1*†, Madhuradhar Chegondi 2†, Marianne E. Ill children are a unique population who frequently receive plasma and platelet transfusions for both active bleeding and mitigation of bleeding risk While these products are frequently administered, transfusion indications in this population remain unclear, and practice varies across institutions and providers. In this manuscript, we will outline the current evidence regarding plasma and platelet transfusions for hemostasis in the pediatric intensive care setting. We will outline the current evidence regarding plasma and platelet transfusions for hemostasis in the pediatric intensive care setting For both products, we will describe the product composition, epidemiology, and product indications and discuss the potential risks and benefits involved with the transfusion.
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