Overview of Plant-Made Vaccine Antigens against Malaria

Marina Clemente,Mariana G Corigliano

doi:10.1155/2012/206918

Marina Clemente, Mariana G Corigliano

Open Access

https://doi.org/10.1155/2012/206918

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Abstract

This paper is an overview of vaccine antigens against malaria produced in plants. Plant-based expression systems represent an interesting production platform due to their reduced manufacturing costs and high scalability. At present, different Plasmodium antigens and expression strategies have been optimized in plants. Furthermore, malaria antigens are one of the few examples of eukaryotic proteins with vaccine value expressed in plants, making plant-derived malaria antigens an interesting model to analyze. Up to now, malaria antigen expression in plants has allowed the complete synthesis of these vaccine antigens, which have been able to induce an active immune response in mice. Therefore, plant production platforms offer wonderful prospects for improving the access to malaria vaccines.

Highlights

Malaria is a major global health problem caused by parasites of the genus Plasmodium
Malaria antigen expression in plants has allowed the complete synthesis of these vaccine antigens, which have been able to induce an active immune response in mice
Plant-derived multiantigen malaria vaccines could be formulated through mixing transgenic plant materials or polycistronic operons in chloroplasts expressing several malaria antigens

Summary

Introduction

Malaria is a major global health problem caused by parasites of the genus Plasmodium. These antibodies recognize proteins expressed on either gametocytes or parasite stages that develop in the mosquito midgut and are considered to be potential malaria vaccine candidates [13] This interruption of parasite transmission from patients to mosquitoes provides the basis for the feasibility of TB vaccines (TBV) of stopping transmission from infected to noninfected people [10]. The high costs estimated for a successful immunization strategy and scalable methods for vaccine production, distribution and delivery, together with the lack of infrastructure in malaria-endemic areas, are the main challenges in the development of a subunit malaria vaccine [20] In this context, the capacity of transgenic plants to produce properly folded proteins at low costs makes them attractive expression systems [24, 25]. This paper is an overview of vaccine antigens against malaria produced in plants

Plant-Made Vaccines

Plant-Made Antigens against the Asexual Blood Stage of Plasmodium

Plant-Made Antigens against Sexual Blood Stage of Plasmodium

Findings

Conclusion