Overview of Peptic Ulcer along with its Conventional and Improvement Therapies: A Study of Glycopyrrolate and Management of Peptic Ulcer

Abstract

Peptic ulcer disease remains a prevalent gastrointestinal disorder globally, posing significant challenges in its management. This comprehensive review provides an overview of peptic ulcer pathology, conventional treatment modalities, and recent advancements in therapeutic approaches. Traditional treatments, among them histamine receptor antagonists, proton pump inhibitors, and antibiotic regimens, have shown efficacy in ulcer healing and symptom alleviation. However, emerging evidence suggests limitations such as drug resistance and adverse effects. In light of these challenges, this article delves into the potential of Glycopyrrolate, a muscarinic receptor antagonist, as a novel therapeutic agent for peptic ulcer management. However, still there may be aggravation of peptic ulcer leading to severe conditions like perforated gastric ulcer, and gastric bleeding where surgery is only beneficial.