Abstract
Since the initial introduction of the dideoxy chain termination method, DNA sequencing has undergone rapid improvement, mainly in the areas of DNA polymerases, deoxynucleotide analogs, and polyacrylamide gel electrophoresis. In this article we review these improvements and their applications to manual DNA sequencing, and we present a brief evaluation of commercial efforts to automate DNA sample preparation, separation, and data acquisition. Included are instruments currently available as well as new concepts potentially amenable to automation.
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