Abstract
Immunosuppressants are used for the management of severe pediatric uveitis cases when the prognosis for vision is poor, in cases of recurrent or chronic uveitis, to achieve corticosteroid sparing or in cases of corticosteroid resistance. Immunosuppressants used in children are anti-metabolites (methotrexate, azathioprine, mycophenolate mofetil), cyclosporine, tacrolimus, and biologics, including adalimumab, infliximab, anakinra, canakinumab, and tocilizumab. The mechanisms of action and indications of the various immunosuppressants used in pediatric uveitis are described in this overview.
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