Abstract
Background Human Endogenous Retroviruses (HERVs) are inherited after ancient germ-line cell infections by exogenous retroviruses. No replication-competent HERVs are known but few of them have one or several intact retroviral genes and retain some physiological effects. The number and classification of human endogenous retroviruses vary according to method of enumeration [1]. The focus of our project is to perform a systematic analysis and a classification of HERVs, in order to better understand their evolution and their involvement in shaping the human genome.
Highlights
Human Endogenous Retroviruses (HERVs) are inherited after ancient germ-line cell infections by exogenous retroviruses
Integration pattern analysis was made by custom algorithms
The 3,290 proviral chains were classified in 57 unique groups which could be placed into class I, II and III
Summary
Human Endogenous Retroviruses (HERVs) are inherited after ancient germ-line cell infections by exogenous retroviruses. No replication-competent HERVs are known but few of them have one or several intact retroviral genes and retain some physiological effects. The number and classification of human endogenous retroviruses vary according to method of enumeration [1]. The focus of our project is to perform a systematic analysis and a classification of HERVs, in order to better understand their evolution and their involvement in shaping the human genome
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