Abstract
Research on attenuating the structural and functional deficits observed following ischemia-reperfusion has become increasingly focused on the therapeutic potential of ischemic postconditioning. In recent years, various methods and animal models of ischemic postconditioning have been utilized. The results of these numerous studies have indicated that the mechanisms underlying the neuroprotective effects of ischemic postconditioning may involve reductions in the generation of free radicals and inhibition of calcium overload, as well as the release of endogenous active substances, alterations in membrane channel function, and activation of protein kinases. Here we review the novel discovery, mechanism, key factors, and clinical application of ischemic postconditioning and discuss its implications for future research and problem of clinical practice.
Highlights
Ischemic preconditioning has been widely adopted as a clinical strategy aimed at protecting the brain from subsequent, more serious ischemia-reperfusion insults
Based on the concept of ischemic preconditioning, research has begun to focus on the development of a nonpharmacological neuroprotective strategy that can be administered following the onset of ischemia
We investigated whether pannexin 1 (Panx1)/P2X7 purinoceptors are involved in the neuroprotective mechanisms of ischemic preconditioning and postconditioning (IPC) in mice [37]
Summary
Ischemic preconditioning has been widely adopted as a clinical strategy aimed at protecting the brain from subsequent, more serious ischemia-reperfusion insults. Ischemic preconditioning involves the application of a brief, subthreshold episode of ischemia prior to the occurrence of irreversible ischemic injury [1]. Based on the concept of ischemic preconditioning, research has begun to focus on the development of a nonpharmacological neuroprotective strategy that can be administered following the onset of ischemia. Most research regarding this strategy—termed ischemic postconditioning—has focused on the heart [4]. Several proof-of-principle studies have yielded promising results for the brain as well [5,6,7]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
