Abstract
Overloading of the macrophage defence system can retard clearance of inert particles from the lung. The purpose of this paper is to compare the burdendependence of clearance of particles and fibres using data from inhalation experiments at the IOM and at RCC, Geneva. Due to the different experimental protocols (in exposure concentrations and periods of exposure and recovery), the comparisons benefit from the use of a mathematical model of retention and clearance. The hypothesis to be investigated is that clearance of short fibres (length < 15 urn) is the same as for non-fibrous particulate dust of low toxicity.
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