Abstract
Twenty six children with overlapping features of more than one connective tissue disorder are reported. The median age of onset was 9.5 years and median duration of follow up 7.5 years. Common presenting symptoms included arthritis, tenosynovitis. Raynaud's phenomenon, myositis, and rashes. At follow up 14 patients had developed sclerodermatous skin changes, but significant systemic involvement was uncommon. Only 16 of the 26 cases had antibodies to nuclear ribonucleoprotein; therefore, 10 did not satisfy criteria for mixed connective tissue disease. It was not possible to differentiate clinical patterns by the presence or absence of any particular antibody profile.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
