Abstract
BackgroundEsophageal squamous cell carcinoma (ESCC) is one of the most aggressive and lethal cancers lacking valid prognostic biomarkers. As an essential component of a large ribonucleoprotein complex, U Three Protein 14a (UTP14a) might play important roles in human tumorigenesis. However, the clinical significance and functions of UTP14a in ESCC still remain unclear.MethodsFrom September 2009 to August 2015, 210 patients with ESCC of the thoracic esophagus underwent thoracoscopic esophagectomy in our institute. The corresponding 210 tissue samples and 30 cancer‐distant mucosa (CDM) samples were tested for UTP14a expression by immunohistochemical staining. The long‐term survival was analyzed by the Kaplan–Meier method and Cox proportional hazards regression analyses. CCK8, cell colony formation, cell cycle, apoptosis, cell invasion, and wound healing assays were carried out with ECA109 cells to evaluate the effects of UTP14a on ESCC in vitro.ResultsUTP14a was positively expressed in 88.1% (185/210) of the ESCC samples. UTP14a expression in ESCC was significantly higher than in CDM, as further confirmed by Western blot analysis. High expression of UTP14a in ESCC correlated significantly with tumor invasive depth (pT stage), which predicts poor disease‐free survival and disease‐specific survival, as indicated by the log‐rank test and Cox proportional hazards regression analysis. Additionally, our in vitro experiments further demonstrated that knockdown of UTP14a inhibits cell proliferation and invasion in ECA109 cells.ConclusionsOur results suggest that UTP14a is aberrantly expressed in ESCC, plays a critical role in cancer progression and could be a potential prognosis predictor of ESCC.
Highlights
Esophageal cancer (EC) is one of the most aggressive and lethal cancers in patients, and it ranks seventh in terms of incidence and sixth in mortality globally.[1]
The histological type of esophageal cancer most often found in Western countries is adenocarcinoma, whereas in China, EC mainly occurs in the form of esophageal squamous cell carcinoma (ESCC).[2]
We found that wild-type p53-induced gene 1 (WIG-1) could effectively reverse the malignant phenotype, suppress cell proliferation, and induce G0/G1 cell cycle arrest and apoptosis in EC109 cells under zinc deficiency conditions.[5,6]
Summary
Esophageal cancer (EC) is one of the most aggressive and lethal cancers in patients, and it ranks seventh in terms of incidence and sixth in mortality globally.[1] The histological type of esophageal cancer most often found in Western countries is adenocarcinoma, whereas in China, EC mainly occurs in the form of esophageal squamous cell carcinoma (ESCC).[2] recent improvements in surgical technology and multidisciplinary treatments could result in better outcomes, the five-year overall survival rate of ESCC. High expression of UTP14a in ESCC correlated significantly with tumor invasive depth (pT stage), which predicts poor disease-free survival and disease-specific survival, as indicated by the log-rank test and Cox proportional hazards regression analysis. Conclusions: Our results suggest that UTP14a is aberrantly expressed in ESCC, plays a critical role in cancer progression and could be a potential prognosis predictor of ESCC
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