Abstract

Background/ObjectivesTranslationally controlled tumor protein (TCTP) exhibits numerous biological functions. It has been shown to be involved in the regulation of glucose. However, its specific role in metabolism has not yet been clearly elucidated. Here, we aimed to assess the effect of TCTP overexpression on metabolic tissues and systemic energy metabolism.Subjects/MethodsWe investigated whether TCTP can ameliorate the metabolic imbalance that causes obesity using TCTP-overexpressing transgenic (TCTP TG) mice. The mice were subjected to biochemical, morphological, physiological and protein expression studies to define the role of TCTP in metabolic regulation in response to normal chow diet (NCD) compared to high-fat diet (HFD) conditions, and cold environment.ResultsWe found that TCTP TG mice show improved metabolic homeostasis under both of NCD and HFD conditions with simultaneous enhancements in glucose tolerance and insulin sensitivity. In particular, we found coincident increases in energy expenditure with significant upregulation of uncoupling protein 1 (UCP1) in the brown adipose tissue (BAT). Moreover, TCTP overexpressing mice exhibit significantly enhanced adaptive thermogenesis of BAT in response to cold exposure.ConclusionsOverexpression of TCTP ameliorated systemic metabolic homeostasis by stimulating UCP1-mediated thermogenesis in the BAT. This suggests that TCTP may function as a modulator of energy expenditure. This study suggests TCTP may serve as a therapeutic target for obesity and obesity-associated metabolic disorders including type 2 diabetes.

Highlights

  • Obesity is a medical condition characterized by an excessive accumulation of body fat, and it is associated with

  • We found that Translationally controlled tumor protein (TCTP) overexpression improves a systemic metabolic status through increasing energy expenditure by uncoupling protein 1 (UCP1)-mediated thermogenesis in mice fed either of normal chow diet (NCD) or high-fat diet (HFD)

  • To explore the phenotypes of TCTPoverexpressing transgenic (TCTP TG) mice, TCTP TG mice were bred under NCD condition, and phenotypical changes were assessed in comparison with WT mice

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Summary

Objectives

We aimed to assess the effect of TCTP overexpression on metabolic tissues and systemic energy metabolism

Methods
Results
Conclusion
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