Abstract
Meeting abstracts Obesity is a major risk factor for metabolic diseases and cancer. Lifestyle interventions in obesity reduce the risk for cancer. Aberrant regulation of dual specificity protein phosphatase 1 (DUSP1) was linked to obesity and cancer representing an attractive therapeutic target and
Highlights
From Updates on Immunotherapy of Cancer and Immunoscore Symposium, part of the Sidra Symposia Series, held in partnership with the Society for Immunotherapy of Cancer Doha, Qatar. 22-23 January 2014
We investigated the effects of a 3-month physical exercise protocol on the expression of dual specificity protein phosphatase 1 (DUSP1) in obese humans and analyzed correlations between DUSP1 levels and study population characteristics
DUSP1 mRNA and protein are highly expressed in the adipose tissue of obese subjects with a concomitant decrease of phospho-p38 MAPK and PGC1a; the two downstream targets of DUSP1 and an increase in the levels of IL-6 and TNF-a inflammatory markers
Summary
From Updates on Immunotherapy of Cancer and Immunoscore Symposium, part of the Sidra Symposia Series, held in partnership with the Society for Immunotherapy of Cancer Doha, Qatar. 22-23 January 2014. Overexpression of the cancer-related DUSP1 gene in human obesity and its modulation by physical exercise Abdelkrim Khadir*, Ali Tiss, Jehad Abubaker, Mohamed Abu-farha, Said Dermime, Mohammed Dehbi
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