Abstract
Increased expression of low voltage-activated, T-type Ca 2+ channels has been correlated with a variety of cellular events including cell proliferation and cell cycle kinetics. The recent cloning of three genes encoding T-type α 1 subunits, α 1G, α 1H and α 1I, now allows direct assessment of their involvement in mediating cellular proliferation. By overexpressing the human α 1G and α 1H subunits in human embryonic kidney (HEK-293) cells, we describe here that, although T-type channels mediate increases in intracellular Ca 2+ concentrations, there is no significant change in bromodeoxyuridine incorporation and flow cytometric analysis. These results demonstrate that expressions of T-type Ca 2+ channels are not sufficient to modulate cellular proliferation of HEK-293 cells.
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