Abstract
S100P has been shown to be overexpressed in various cancers and to have putative involvement in the metastatic process. However, Clinical and pathological significance of S100P expressionin colorectal cancer still needs to be further studied. In the present study, the method of immunohistochemistry was utilized to investigate S100P protein expression in 91 cases of colorectal cancer. Also, the influence of ectopic expression of S100P on the biologic behavior in SW480 colorectal cancer cells was studied. We found that S100P expression of colorectal cancer tissue was significantly higher than that of normal colorectal mucosal tissues. S100P expression showed to be significantly correlated with clinical staging, lymph node metastasis and recurrence. Ectopic expression of S100P promotes SW480 cancer cells migration and invasion, decreases chemosensitivity to 5-FU in vitro. These findings suggested that S100P could serve as a promising candidate for colorectal cancer marker, prognostic indicator, and therapeutic target.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
