Abstract
Background: Cardiac glucose metabolism changes during the progression of heart failure. Phosphoglycerate mutase (PGM) is a glycolytic enzyme, and is also known to regulate the stress resistance of cells. We assessed the hypothesis that PGM regulates cardiac function and stress resistance of the heart. Methods and Results: To examine the role of PGM in heart failure, we created and characterized transgenic mice overexpressing PGM in a heart-specific manner. Two transgenic lines were obtained. PGM transgenic lines survived normally up to 12 months.
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