Overexpression of p53R2 is associated with poor prognosis in lung sarcomatoid carcinoma

Jiewei Chen,Yongbo Xiao,Jun Liu,Xiaoyan Cai,Keming Chen,Xinke Zhang

doi:10.1186/s12885-017-3811-6

Abstract

BackgroundThis study aimmed to evaluate the expression of p53-inducible RR small subunit 2 homologue (p53R2) in Lung sarcomatoid carcinoma (LSC) and its association with clinicopathological parameters and prognosis.MethodsIn this study, clinicopathological factors and prognostic significance of the expression of p53R2 was investigated by immunohistochemistry (IHC) in 100 cases of LSC.ResultsThe results showed that the expression of p53R2 was significantly correlated with clinical stage (P<0.05). But there was no statistically correlation with gender, age, smoking, tumor size, pT stage, pN stage, pM stage, therapy and relapse. Kaplan-Meier analysis revealed that the expression of p53R2, clinical stage, pT stage, pN stage, pM stage and tumor size were closely related to patients’ survival, and the analysis also revealed that patients with low expression of p53R2 had a longer overall survival than that with high expression (Mean overall survival: 84.8 months vs. 34.7 months, P<0.05). Further multivariate analysis indicated that the expression of p53R2 was identified as an independent prognostic factor in the prediction of the overall survival for patients with LSC (HR = 3.217, P<0.05).ConclusionsThe expression of p53R2 was inversely associated with the proliferation and progression of LSC, and the results indicated that the high expression of p53R2 was an independent factor for unfavorable prognosis of patients with LSC.

Highlights

This study aimmed to evaluate the expression of p53-inducible Ribonucleotide reductase (RR) small subunit 2 homologue (p53R2) in Lung sarcomatoid carcinoma (LSC) and its association with clinicopathological parameters and prognosis
Immunohistochemical results showed that p53-inducible RR small subunit homologue (p53R2) protein was mainly located in the cytoplasm of LSC (Fig. 1)
Selection of cutoff value for p53R2 expression To choose a suitable cutoff score of p53R2 for further analysis, each clinicopathological parameter is used to analyze in the receiver operating characteristic (ROC) curve, respectively (Fig. 2), samples with score more than or equal to the obtained cutoff value were seen as high expression of p53R2

Summary

Introduction

This study aimmed to evaluate the expression of p53-inducible RR small subunit 2 homologue (p53R2) in Lung sarcomatoid carcinoma (LSC) and its association with clinicopathological parameters and prognosis. 2016 Cancer statistics show that morbidity and mortality of lung cancer rank second, and is obviously threatening human health in the United States [1]. Lung sarcomatoid carcinoma (LSC) is a subtype of non-small cell lung cancer (NSCLCs) with histology containing sarcoma or sarcomatoid differentiation. The incidence of LSC represent appropriately from 0.1% to 0.4% in lung malignancies [2], and approximately 2.35% of NSCLCs [3]. The rare proportion is occurred, nearly 2000 cases were diagnosed as LSC per year in the United. LSC is characterized by highly malignant and easy to relapse [5].

Methods

Results

Discussion

Conclusion