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Abstract
Background: DNA methylation is an epigenetic marker associated with regulation of gene expression and gene silencing. The active role of DNA methylation has been thoroughly studied in a number of cancer types. The deleted in colorectal carcinoma (DCC) gene, located at chromosome 18q21, plays an important role as a tumor suppressor and is associated with hypermethylation in head and neck squamous cell carcinoma. However, the methylation patterns and functional significance of DCC in lung cancer are still not known.
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