Abstract
BackgroundLong non-coding RNAs (lncRNAs) play important roles in lung tumorigenesis. Among different lncRNAs, overexpression of the lncRNA actin filament‐associated protein 1‐antisense RNA 1 (AFAP1-AS1) in lung tumors has been reported in different studies. In the current study, we aimed to investigate the potential value of lncRNA AFAP1-AS1 as a diagnostic biomarker in lung cancer. Ninety samples from patients with lung cancer were collected from Noor-E-Nejat hospital, Tabriz, Iran. The expression of AFAP1-AS1 was assessed using quantitative reverse transcriptase-PCR (qRT-PCR), followed by the ROC curve analysis to investigate the biomarker potency of AFAP1-AS1.ResultsOur results revealed an upregulation of AFAP1-AS1 in tumor samples as compared to the adjacent non-tumor tissues. We found a significant positive association between AFAP1-AS1 expression and tumor size, as well as tumor stage.ConclusionsOur results showed overexpression of AFAP1-AS1 and its capacity as a diagnostic biomarker in lung cancer.
Highlights
Long non-coding RNAs play important roles in lung tumorigenesis
The objective of the current study was to determine AFAP1-AS1 expression levels in non-small cell lung cancer (NSCLC) tumors compared to non-tumor tissues
Patients A total number of ninety NSCLC patients were included in the study
Summary
Long non-coding RNAs (lncRNAs) play important roles in lung tumorigenesis. Among different lncRNAs, overexpression of the lncRNA actin filament‐associated protein 1‐antisense RNA 1 (AFAP1-AS1) in lung tumors has been reported in different studies. We aimed to investigate the potential value of lncRNA AFAP1-AS1 as a diagnostic biomarker in lung cancer. Cancer is one of the most important health burdens and the second cause of death worldwide [1]. Lung cancer is the second most common malignancy after breast cancer in women and prostate cancer [2, 3]. It has been shown that tobacco smoking is one of the main risk factor of lung cancer susceptibility [4]. Lung cancer in never smokers may be associated with genetic and epigenetic profiles and with environmental
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