Abstract
Molecular remodeling in the heart caused by hypertrophy differs between physiological and pathological stimuli. The main goal of this study was to determine how cardiac hypertrophy that is induced by pressure overload or endurance training influences lipid metabolism in the myocardium. The expression of lipogenic genes was upregulated in exercise‐induced hypertrophy and was accompanied by the activation of fatty acid (FA) oxidation pathways regulated by AMPK and RRARα. Intracellular diacylglyceride (DAG), triglyceride (TG) and free FA were not changed in trained compared with untrained hearts. In contrast, in the heart with abdominal aortic banding (AAB)‐induced hypertrophy, we found an increased accumulation of TG and DAG, although the expression of lipogenic genes and the level of FA transport proteins were not augmented. Cardiac steatosis in AAB‐induced hypertrophy was associated with decreased lipolysis, as evidenced by increased hormone‐sensitive lipase phosphorylation at Ser565 and decreased DAG lipase‐α and ‐β protein levels. Obtained results show that cardiac lipid metabolism is differentially regulated in response to physiological and pathological hypertrophic stimuli and suggest that activation of lipogenesis might be involved in the regulatory mechanisms of heart adaptation to stress. Support: NCN UMO‐2011/01/D/NZ3/04777, NCBR LIDER/19/2/L‐2/10/NCBiR/2011.
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