Abstract
Background and Objectives: Patients with oral squamous cell carcinoma (OSCC), a common malignancy in Asian countries, have a poor prognosis. We investigated the role of Krüppel-like factor 17 (KLF17) and its prognostic significance in OSCC. Materials and Methods: KLF17 expression was measured by immunohistochemical staining of specimens from 283 patients with OSCC. We analyzed correlations between KLF17 expression and clinicopathologic features and between KLF17 expression and overall survival. The prognostic value of KLF17 was tested using Kaplan–Meier analysis and Cox proportional hazard models. Results: Among the 283 patients, high KLF17 expression was significantly associated with an early OSCC stage and low T-value (p = 0.033 and p = 0.036, respectively). The five-year survival rates were better in patients with high KLF17 expression than with low expression (66.5% and 49.6%, respectively). The prognostic role of KLF17 was further confirmed through multivariate analysis (hazard ratio 1.506, 95% confidence interval 1.034–2.191, p = 0.033). The prognostic value was more significant in patients with a history of betel quid chewing or with a low T-value. Conclusions: High KLF17 expression can serve as a marker for a favorable prognosis in patients with OSCC. The prognostic role of KLF17 is more significant in patients with a history of betel quid chewing or a low T-value.
Highlights
Oral cancer is one of the most common malignancies in the world
We verified the relationships between Krüppel-like factor 17 (KLF17) expression and the clinical parameters by recruiting recruiting 283 patients with oral squamous cell carcinoma (OSCC), and we evaluated KLF17 expression by IHC staining of 283 patients with OSCC, and we evaluated KLF17 expression by IHC staining of microarray sections microarray sections (Figure 1)
The scores by the pathologists for the intensity of the KLF17 expression in the nuclei revealed expression in the nuclei revealed that KLF17 expression was significantly associated with tumor stage that KLF17 expression was significantly associated with tumor stage and T-value
Summary
Oral cancer is one of the most common malignancies in the world. In 2018, an estimated354,864 new cases of lip and oral cavity cancer were diagnosed worldwide and 177,384 cancer deaths were recorded [1]. Medicina 2020, 56, 57 oral cancer is an urgent need [3,4,5,6] These biomarkers can contribute to clinical decision making and increase survival rates in patients with early-stage oral cancer. Patients with oral squamous cell carcinoma (OSCC), a common malignancy in Asian countries, have a poor prognosis. Results: Among the 283 patients, high KLF17 expression was significantly associated with an early OSCC stage and low T-value (p = 0.033 and p = 0.036, respectively). The five-year survival rates were better in patients with high KLF17 expression than with low expression (66.5% and 49.6%, respectively). The prognostic role of KLF17 is more significant in patients with a history of betel quid chewing or a low T-value
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