Abstract
(Cancer Cell 14, 408–419; November 4, 2008) In the first paragraph of the Introduction of this paper, the sentence “Gastric adenocarcinoma is the second most common cancer in the world and is strongly linked to chronic inflammation (Fox and Wang, 2007)” is incorrect. The correct sentence should read “Gastric adenocarcinoma is the second most common cause of cancer-related mortality in the world and is strongly linked to chronic inflammation (Fox and Wang, 2007).” The phrase “-related mortality” was inadvertently deleted; the authors sincerely apologize for this inaccuracy. Overexpression of Interleukin-1β Induces Gastric Inflammation and Cancer and Mobilizes Myeloid-Derived Suppressor Cells in MiceTu et al.Cancer CellNovember 04, 2008In BriefPolymorphisms of interleukin-1β (IL-1β) are associated with an increased risk of solid malignancies. Here, we show that stomach-specific expression of human IL-1β in transgenic mice leads to spontaneous gastric inflammation and cancer that correlate with early recruitment of myeloid-derived suppressor cells (MDSCs) to the stomach. IL-1β activates MDSCs in vitro and in vivo through an IL-1RI/NF-κB pathway. IL-1β transgenic mice deficient in T and B lymphocytes develop gastric dysplasia accompanied by a marked increase in MDSCs in the stomach. Full-Text PDF Open Archive
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