Abstract
Intercellular cell adhesion molecule-1 (ICAM-1), an important adhesion molecule in the immunoglobulin superfamily, is expressed on many cell types. Recent studies have identified ICAM-1 as a potential oncogene that promotes the development of epithelial ovarian cancer (EOC); it was also found to be associated with poor survival. However, the clinical significance of its expression in high-grade serous ovarian carcinoma (HGSOC) is unclear. Thus, this study aimed to investigate the significance of ICAM-1 expression in HGSOC. Data on ICAM1 expression and mutations in serous ovarian carcinoma (SOC) were obtained from the Cancer Genome Atlas (TCGA), and ICAM1 mRNA expression data in HGSOC were obtained from the Gene Expression Omnibus (GEO) database. ICAM-1 expression was evaluated by immunohistochemistry in HGSOC and normal fallopian tube tissues microarray. In TCGA data, amplification/mutation of ICAM1 was identified in 12% of serous ovarian carcinoma samples, and overexpression of ICAM1 mRNA predicted reduced overall survival in SOC. From TCGA and GEO data, SOC patients with ICAM1 mRNA overexpression treated with chemotherapeutic drugs that contained taxol or taxol and platin together had significantly reduced progression-free survival. According to GEO data, ICAM1 mRNA expression was found significantly higher in HGSOC than in control samples. In our study, ICAM-1 overexpression was observed in 63.1% (65/103) of HGSOCs. As a prognostic biomarker, overexpression of ICAM-1 predicted reduced recurrence-free and overall survival and is an independent risk factor for poor prognosis. These findings suggest that overexpression of ICAM-I is an independent indicator of poor prognosis for HGSOC and that it can serve as an effective clinical prognostic biomarker for this disease.
Highlights
Ovarian carcinoma is the most lethal gynecological malignancy worldwide [1]
From the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) data, serous ovarian carcinoma (SOC) patients with ICAM mRNA overexpression treated with chemotherapeutic drugs that contained taxol or taxol and platin together had significantly reduced progression-free survival
Combined Kaplan–Meier Plotter analysis of TCGA and GEO data revealed that SOC patients with ICAM mRNA overexpression treated with chemotherapeutic drugs that contained taxol or taxol and platin together had significantly reduced progression-free survival compared to that in SOC patients with low ICAM expression
Summary
Ovarian carcinoma is the most lethal gynecological malignancy worldwide [1]. High-grade serous ovarian carcinoma (HGSOC), the most common subtype, accounts for 75–80% of epithelial ovarian carcinomas (EOCs) [2]. Due to a lack of effective biomarkers for early detection and screening, approximately 75% of patients with HGSOC are diagnosed at advanced stages, and the 5-year overall survival rate (20–30%) has not significantly improved over the last 20–30 years [3, 4]. Exploring novel biomarkers involved in HGSOC progression and prognosis would contribute to early diagnosis and provide therapeutic targets. Intercellular cell adhesion molecule-1 (ICAM-1), known as CD54, is an important adhesion molecule of the immunoglobulin superfamily. As a transmembrane leukocyte and endothelial cell protein, ICAM-1 enhances tumor cell adherence to endothelial cells [5]. An increasing number of studies have elucidated that ICAM-1-mediated interactions with macrophages enhance the immunosuppressive function of human mesenchymal stem cells [6], and ICAM-1 overexpression enhances rhinovirus replication in monocytic cells
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
