Abstract
Heat shock protein 27 (HSP‑27) is a member of the small-molecular-weight HSP family, the expression of which is increased when cells are exposed to elevated temperatures or any other kinds of stress; it seems that the cellular protective properties this protein demonstrates might also help cancer cells stay immortal. Family members of HSPs are either expressed continuously or controlled inductively, and are present in different subcellular structures. The aim of this study was to investigate the prognostic value of HSP‑27 expression in the histological grades of oral squamous cell carcinoma (OSCC). In the present study, HSP‑27 expression was compared immunohistochemically among 30 cases with OSCC (15 men and 15 women), ranging between 22 and 74 years of age (mean age: 48 years). The cases were divided into 3 groups (n = 10) according to the histological grade. While all grades expressed HSP‑27 in the cancerous epithelial cells, the intensity of expression rose gradually from grade 1 to grade 3 tumors (grade 1 < grade 2 < grade 3). The statistical analysis indicated significant differences between the 3 groups (p = 0.000). This study has found that HSP‑27 may be used as a marker for the histological grades of OSCC and that its expression may be an indicator of the biological behavior of the tumor.
Highlights
Heat shock proteins (HSPs) are conserved molecu‐ lar chaperones; they are ubiquitous and have several functions in cellular homeostasis, including the regu‐ lation of gene expression, the replication of DNA, the transduction of signals, differentiation, apoptosis, and cellular survival or immortalization
Heat shock protein 27 (HSP‐27) is a member of the small-molecular-weight HSP family, the expression of which is increased when cells are exposed to elevated temperatures or any other kinds of stress; it seems that the cellular protective properties this protein demonstrates might help cancer cells stay immortal
The aim of this study was to investigate the prognostic value of HSP‐27 expression in the histological grades of oral squamous cell carcinoma (OSCC)
Summary
Heat shock proteins (HSPs) are conserved molecu‐ lar chaperones; they are ubiquitous and have several functions in cellular homeostasis, including the regu‐ lation of gene expression, the replication of DNA, the transduction of signals, differentiation, apoptosis, and cellular survival or immortalization. They protect cells from various kinds of stress, such as hypoxia, ischemia or rapid increases in temperature.[1]. Heat shock protein 27 belongs to the family of small HSPs, which play essential roles in cells under physio logical conditions and prevent cells from damage caused by stress. Members of HSPs are either expressed continuously or controlled inductively, and are present in different subcellular structures
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have