Abstract
Long non-coding RNAs (lncRNAs) associated with the tumorigenesis of human cancers. However, the relevance of lncRNAs in tongue squamous cell carcinoma (TSCC) is still unclear. To discover novel TSCC-related lncRNAs, we analyzed the lncRNA expression patterns in two sets of TSCC gene expression profile data, and found that long intergenic non-coding RNA 673 (LINC00673) was significantly upregulated in TSCC samples. Then we examined LINC00673 expression in 202 TSCC tissue specimens, LINC00673 is highly expressed in a significant proportion of human TSCC biopsies and correlates with poor prognosis. Knockdown LINC00673 significantly inhibited the cell invasion and migration capability in TSCC cells. Our findings suggest that LINC00673 may play an essential role in TSCC progression and might serve as a potential biomarker for early detection and prognosis prediction of TSCC.
Highlights
Head and neck cancer is the sixth most common malignant tumors all around the world, accounting for approximately 6% of all cancers mortality [1,2,3]
To investigate the role of Long non-coding RNAs (lncRNAs) in tongue squamous cell carcinoma (TSCC) tumorigenesis, we focused on LINC00673, for which the expression was most significantly different and had never been reported in human cancer
Recent reports indicate that lncRNAs play a critical role in a wide range of tumor progression such as differentiation, proliferation, and metastasis [32,33,34]
Summary
Head and neck cancer is the sixth most common malignant tumors all around the world, accounting for approximately 6% of all cancers mortality [1,2,3]. Epithelial tumors arising in the oral cavity is the most high-frequently occurred cancer in head and neck region, and tongue squamous cell carcinoma (TSCC) is the most common histological malignancy of in this region [4]. Recent studies have identified multiple functional effects of lncRNAs involving in various cellular processes, such as tumor initiation, progression and metastasis, and the dysregulation of lncRNAs are a primary feature of some human cancers [16,17,18,19]. A great quantity identified results revealed that lncRNAs play an important role in pathogenesis of head and neck cancers [20,21,22]. The TSCC associated lncRNAs and their influence on TSCC cellular progress need to be elucidated further
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