Overexpressed transcription factor FOXM1 is a potential diagnostic and adverse prognostic factor in postoperational gastric cancer patients

Abstract

In the present study, we intend to detect the expression of Forkhead box transcription (FOXM1) in gastric cancer tissues and cell lines, and analyze the correlation between FOXM1 expression and clinic-pathological features as well as their association with clinic outcomes in patients with resectable gastric cancers. We examined the expression of FOXM1 in 103 cancer tissues from patients who underwent gastrectomy during Jan 2007 to Nov 2007 and 68 randomly selected para-cancer tissues by immunohistochemistry. The expression of FOXM1 protein in the benign and malignant human gastric cell lines was simultaneously detected using Western blot analysis. Data on clinic-pathological features and relevant prognostic factors in these patients were then analyzed. FOXM1 expression was absolutely higher in gastric cancer than para-cancer tissues (P<0.001) and normal gastric epithelium cell lines (P=0.022). No significant association was found between FOXM1 expression and any clinic-pathological parameters (P>0.1). FOXM1 amplification was showed to be independently associated with prognosis in gastric cancer patients (P=0.001), and its affection is more significant in patients with tumor size larger than 5cm (P=0.004), pT3-4 (P=0.003) or pIII-IV (P=0.001) as a result of stage-stratified analysis. Overexpressed FOXM1 is a potential diagnostic and poor prognostic biomarker in postoperational gastric cancer patients.