Abstract
Ovarian cancer (OV) is an epithelial malignancy that intrigues people for its high mortality and lack of efficient treatment. Chemokine-like factor (CKLF)–like MARVEL transmembrane domain containing 6 (CMTM6) can be observed in various cancers, but its part in OV remains little known. Hence, the prognostic value and underlying mechanism of CMTM6 in OV were preliminarily evaluated. Here, we determined that CMTM6 expression was higher than that in normal controls. However, the upregulation of CMTM6 was associated with better prognosis. GSEA results suggested that CMTM6 is involved in the immune-related and metabolism-related pathways. GO/KEGG analysis of CMTM6 coexpressed genes was performed to survey the possible regulatory roles of CMTM6 in OV. Subsequently, CMTM6 expression was positively correlated with the infiltration levels of immune cells and the expression of diverse immune cell marker sets. Importantly, CMTM6 may influence prognosis partially by regulating immune infiltration in OV. Last, copy number variations (CNVs) and DNA methylation might prompt the abnormal CMTM6 expression in OV. In conclusion, CMTM6 can serve as a novel prognostic biomarker in patients with OV.
Highlights
The fatality rate of ovarian cancer (OV) is the highest among all female reproductive tract tumors (Ferlay et al, 2015)
According to the GEPIA2 database query, we found that CMTM6 expression was upregulated in COAD, GBM, LAML, LGG, Ovarian cancer (OV), PAAD, READ, STAD, THCA, and UCEC, especially in OV, compared with the corresponding normal tissues (Figure 1A)
Higher mRNA expression of CMTM6 by the Oncomine database was observed in OV patients than that in normal samples (Figures 1B–F)
Summary
The fatality rate of ovarian cancer (OV) is the highest among all female reproductive tract tumors (Ferlay et al, 2015). Breakthrough has been made in the screening and prevention and targeted therapies to improve the survival of OV patients, there was no definitive mortality reduction (Lisio et al, 2019) In view of these circumstances, it is imperious to discover a promising biomarker or new targets that make substantial contribution to improve patient prognosis. The human chemokine-like factor (CKLF)–like MARVEL transmembrane domain-containing (CMTM) is a gene family consisting of nine members, CKLF and CMTM1–8 (Han et al, 2001; Han et al, 2003) Their encoded products are structurally and functionally intermediate classical chemokines and the transmembrane 4 superfamily (TM4SF), which play important roles in the immune system, tumorigenesis, cell cycle, and the male reproductive system (Zheng et al, 2011; Li et al, 2014; Liu et al, 2019)
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