Overeating, alcohol and sucrose consumption decrease in CB1 receptor deleted mice

Abstract

Administration of the cannabinoid CB1 receptor antagonist SR141716 (3–10 mg/kg i.p.) abolished neuropeptide Y-induced overeating and significantly reduced ethanol and sucrose intake in CB1 wild-type (+/+) mice. In CB1 receptor knockout (−/−) mice, neuropeptide Y totally lost its capacity to increase food consumption. Similarly, sucrose and ethanol intakes were significantly lower in CB1−/− vs. CB1+/+ mice. In CB1 deficient mice, SR141716 had no effect in these models.