Overcoming the antibiotic resistance of Acinetobacter baumannii by using nanofluid containing functionalized carbon nanotubes

Abstract

Objective: Acinetobacter baumannii is critical for healthcare-associated infections with significant regional differences in the resistance rate, but its risk factors and infection trends have not been well studied. Carbon nanotubes are substantially cylindrical molecules made entirely of carbon atoms and can use as nanocarriers. Multi-wall carbon nanotubes, through their unique properties, hold great promise in the fight against multidrug-resistant bacterial infections. In this research, antimicrobial effects study and the ability to overcome antibiotic resistance evaluation of nanofluid containing functionalized carbon nanotubes on A. baumannii were done. Methods: Multi-wall carbon nanotubes provided from the United States Research and the nanofluid prepared after carbon nanotube functionalization. Microplate, Alamar Blue Cell viability assay, carried out after incubation of A. baumannii affected with the nanofluid (100µg/ml) for 24h. Results: Antimicrobial effect of functionalized carbon nanotubes nanofluid was found on the A. baumannii in a dose-specific concentration manner. Conclusion: This study showed that functionalized carbon nanotubes nanofluid could have antimicrobial effects on A. baumannii by overcoming bacterial antibiotic resistance. Although to get more accurate results, to prevent nosocomial infections, more specific cellular and molecular studies are necessary.