Abstract
60%-70% Several drugs can be administered orally as liquids, capsules, tablets, or chewable tablets because the oral route is the most convenient, safest and less expensive. The important challenge in the oral drug delivery is the growth of novel approaches to approve absorption of poorly permeable drugs across the intestinal permeability. The Biopharmaceutics Classification System (BCS) categorized based on their solubility and permeability. The BCS Class III, Class IV with low permeability across the biological membranes with low bioavailability. While these drugs are pharmacologically effective, poor absorption due to low permeability becomes the rate-limiting step to improve oral bioavailability. Various approaches for improving the permeability include physical, chemical, colloidal carriers and other methods such as prodrugs, permeation enhancers, ion-pairing, nanoencapsulation and combination/hybridization of one or more traditional approaches to improve drug permeability for better absorption. Among many advantages over other routes of administration 3 crucial ones are avoiding metabolism in liver, minimal negative effects and increased bioavailability.This article discusses the commonly various strategiesand various approaches for improving the permeability of BCS Class III and Class IVdrugs to enhance bioavailability.
Highlights
60%-70% Several drugs can be administered orally as liquids, capsules, tablets, or chewable tablets because the oral route is the most convenient, safest and less expensive
Bile salts are capable to bind with calcium, their binding properties decreases with increasing hydrophilicity
A combination of the lipophilic prodrug approach with lipid-based formulation resulted in efficient targeting of LPV to HIV reservoirs in mesenteric lymph and MLNs
Summary
Copy rights@ Abbaraju Krishna Sailaja. et al. to interact with solubility drugs and drug candidates resulting in an increase in the drug’s apparent water solubility and dissolution rates. The SFD processed OA formulation and commercial OA tablet generally exhibit large interanimal variability in oral bioavailability, compatible with the absorption of BCS class IV compounds which are poorly permeable drugs. Self-micro-emulsifying drug delivery systems (SMEDDS): The GI absorption of poorly permeable drugs i.e. BCS class 4 drugs can be improved by using self-microemulsifying drug delivery systems These systems are isotropic mixtures of oils, surfactants and cosolvents /co-surfactants. Self-double emulsifying drug delivery system (SDEDDS): The self-double emulsifying drug delivery systems (SDEDDS) can be used for improving oral bioavailability of drugs with high solubility and low permeability BCS Class III, but their industrial application is sufficient because of low stability. The internal aqueous droplets encapsulated by the oil membrane for hydrophilic drugs This structure can safeguard the drug dissolved in the internal aqueous phase and promising for improving oral bioavailability of compounds [5,6]
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