OVER SERÖZ KARSİNOMUNDA VE BORDERLİNE SERÖZ TÜMÖRDE İMMÜNHİSTOKİMYASAL PINCH/LIMS-1 ANTİKOR EKSPRESYONUNUN KLİNİKOPATOLOJİK DEĞERİ

Abstract

Objective
 Particularly interesting cys-his rich protein (PINCH/
 LIMS-1), a protein implicated in cell adhesion, is
 assumed to oversee the development and invasion of
 cancer cells in tumors and tumor-associated stroma.
 This study aimed to assess PINCH-1 expression in
 serous borderline tumor (SBT) and serous carcinoma
 (SC) in the tumor and peritumoral stroma and
 scrutinize any associations between its expression
 and various clinical and pathological parameters.
 Material and Method
 In this study, the expression of the PINCH-1 antibody
 was analyzed in 21 cases of SBT and 89 cases of
 SC using the indirect immunoperoxidase technique
 with streptavidin/HRP-biotin. The staining pattern of
 PINCH-1 in the tumor and peritumoral stroma was
 evaluated using a semiquantitative scoring method.
 The staining procedure used in the study allowed for
 the accurate identification of PINCH-1 expression,
 and the data obtained through the semiquantitative
 scoring method provided a reliable of assessing
 the degree and intensity of PINCH-1 staining. Thus,
 the correlation between PINCH-1 expression and
 various pathologic factors such as patient age, tumor
 size, FIGO stage, intra-abdominal washing cytology,
 capsule invasion, tumor location in the ovary, tumor
 grade, and cancer antigen 125 (CA125) levels at the
 time of diagnosis was examined.
 Results
 The study found that PINCH-1 was more prevalent
 in cases of SC than in SBT cases. The tumors in SC
 cases had stronger staining than those in SBT cases
 (p