Abstract
Purpose/Objective: Inherited defects in genes associated with DNA mismatch repair (MMR) have been linked to familial colon cancer. Many sporadic human cancers also show abnormalities in MMR gene function and expression, typically due to epigenetic alterations of promoter activity. Cells deficient in MMR are genetically unstable and demonstrate a tolerance phenotype to several cytotoxic DNA damaging agents in clinical use, including cisplatin and ionizing radiation. This study was carried out to determine the effect of over-expression of MMR genes on genome integrity and response to ionizing radiation and other agents.
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More From: International Journal of Radiation Oncology*Biology*Physics
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