Abstract
Dry eye mainly occurs in perimenopausal women, perimenopausal women with ovarian atrophy, estrogen and androgen levels showed a significant downward trend, and androgen related Estrogen Progesterone and prolactin receptors are widely distributed in lacrimal gland, meibomian gland, cornea and other tissues. The purpose of this study was to investigate the effect of ovariectomy on the ultrastructure of meibomian gland epithelial cells in rats. At the same time, we used the laboratory experiment method to select the non ovariectomized rats and ovariectomized rats were divided into two groups. After ovariectomy, we studied the effect of ovariectomy on the ultrastructure of meibomian gland epithelial cells in rats, objective to investigate the curative effect of palpebral margin in the treatment of moderate and severe meibomian gland dysfunction.The results showed that the ultrastructure of meibomian gland epithelial cells had obvious pathological changes after ovariectomy. It can improve 90% of female patients’ subjective symptoms and severity, increase tear secretion and reduce corneal fluorescein staining, reduce tear film damage, enhance the stability of tear film, and restore meibomian gland function. The treatment effect is significant. It can lay the foundation for the future clinical treatment of meibomian gland dysfunction and other related dry eyes, and it can also become an effective new treatment for postmenopausal women.
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