Abstract
Objective To determine the effect of withdrawal of ovarian hormones on the occurrence of absence seizures in WAG/Rij rats, a well-validated animal model for absence epilepsy. Methods Two weeks after electroencephalography (EEG) electrodes were implanted, video-EEG recordings of 16 adult female WAG/Rij rats were made. The rats were then randomly assigned to undergo ovariectomy or sham surgery. One week after surgical procedures, EEG recordings were made for five consecutive days. The EEGs were amplified and filtered between 1 and 100 Hz and digitized at 200 Hz. Results In the ovariectomy group, both duration and the number of spike-wave discharges increased. Conclusion The present data suggest that ovariectomy enhances the occurrence of spike-wave discharges and absence seizures in WAG/Rij rats.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
