Abstract
Ovarian endocrine activity in association with hormonally active and inactive neoplasia is a well-known fact. The question whether or not the tumor cells themselves or the stroma participate in steroidogenesis deserves consideration. To contribute to the solution of this problem a number of 28 primary ovarian tumors (thecoma, adenothecoma, fibroma, adenofibroma, cystadenoma, cystadenocarcinoma, and dysgerminoma) have been studied by histochemical and enzyme histochemical methods. Steroid-producing cells are characterized by the enzymes secondary alcohol dehydrogenase and 3β-ol hydroxysteroid dehydrogenase and indicated by NADP-tetrazolium reductase, glucose-6-phosphate dehydrogenase, and isocitrate dehydrogenase. The combination of the total number of endocrine-active cells and the quantity of the enzymes per cell seem to determine the clinical effect of the steroids produced.
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