Ovarian sensitivity index is a new cost-effective parameter for ovarian responsiveness in an IVF/ICSI cycle

Abstract

Objective The aim of this study was to validate the use of the ovarian sensitivity index (OSI) in predicting ovarian response and thus calculating the optimal human menopausal gonadotropin dose to reach a desirable ovarian response in invitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles. Study design This study was an observational one. Setting The study was conducted in University Hospital IVF Center. Patients A total of 731 patients undergoing IVF/ICSI treatment cycle were included in the study. Results The OSI correlated with ovarian reserve parameters, positively with antral follicle count and anti-Müllerian hormone, and inversely with follicle stimulating hormone, age, and BMI (P<0.001 for all except BMI, for which P=0.018). Moreover, the OSI showed a significant inverse correlation with ovarian response parameters: the total dose of gonadotropin administered, average daily dose of gonadotropin, and duration of stimulation (P<0.001). Conclusion The OSI is a reliable parameter for ovarian responsiveness and can be used to calculate the optimal human menopausal gonadotropin dose to reach a desirable ovarian response in ICSI cycles.