Abstract
Objective:To determine the ovarian reserve parameters in patients presenting for IVF and intracytoplasmic sperm injection (ICSI) treatment and its association with the number of follicles retrieved and number of oocyte retrieved and fertilized.Methods:A retrospective cross sectional study was conducted at Australian Concept Infertility Medical Centre from January 2017 to August 2017. Around 120 couples presenting to infertility clinics selected for IVF and ICSI with Females (25-45) had their FSH, AMH and AFC done. After ovulation induction, its response was determined by number of follicles retrieved, quality of oocytes retrieved or fertilized and inseminated. SPSS version 20 was used for the purpose of data analysis.Results:The median age of the patients was 34 (29-38) years. A moderate negative correlation of age and FSH levels was observed with quality of oocytes, Number of oocyte inseminated, number of oocyte fertilized and number of follicle restored. However, a positive correlation of AMH and AFC levels were found with quality of oocytes, Number of oocyte inseminated, number of oocyte fertilized and number of follicle restored. The correlation of AMH levels with number of oocyte inseminated (rho 0.729, p-value <0.001), number of oocyte fertilized (rho 0.721, <0.001) and number of follicle restored (rho 0.723, p-value <0.001) were found strongly correlated.Conclusion:Our study concluded that AMH and AFC have a strong correlation with number of follicles restored and number of oocytes retrieved whereas FSH and age has a weak correlation with the number of follicles restored and number of oocytes retrieved.
Highlights
Ovarian reserve is a measurement of the ovarian follicular pool[1] and determines the capacity of the ovary to produce oocytes that are capable of fertilization
intracytoplasmic sperm injection (ICSI) was found significantly higher among patients with primary infertility type than that of secondary infertility type whereas Intra Cytoplasmic Sperm Injection – Gender Selection (ICSI-GS) and Frozen Embryo Transfer (FET) procedures were found significantly higher among patients with secondary type of infertility
Correlation of oocytes with ovarian reserve parameters: A moderate negative correlation of age and Follicular stimulating hormone (FSH) levels were observed with quality of oocytes, number of oocyte inseminated, number of oocyte fertilized and number of follicle restored
Summary
Ovarian reserve is a measurement of the ovarian follicular pool[1] and determines the capacity of the ovary to produce oocytes that are capable of fertilization. Age is one of an important factor for ovarian reserve quality and quantity determination.[1] Follicular stimulating hormone (FSH) is the test widely used for ovarian reserve.[2] Serum Antimullerian hormone (AMH) is a reliable marker that reflects the acyclical ovarian activity. This marker is operator independent and there is strong correlation in predicting ovarian reserve,[3] it is a glycoprotein secreted by the granulosa cells of the developing ovarian follicles. It is a serum marker for the measurement of ovarian reserve and
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