Ovarian reserve in nigerian women with sickle cell anaemia: a cross- sectional study

Sunusi Rimi Garba,Christian Chigozie Makwe,Olufunto Olufela Kalejaiye,Vincent Oluseye Osunkalu,Adaiah Priscillia Soibi-Harry,Bosede Bukola Afolabi,Amina Umar Aliyu

doi:10.1186/s13048-021-00927-5

Sunusi Rimi Garba, Christian Chigozie Makwe + Show 5 more

Open Access

https://doi.org/10.1186/s13048-021-00927-5

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Abstract

IntroductionSickle cell disease is the most common monogenetic disorder worldwide. There have been reports of endocrine dysfunction and gonadal failure among affected individuals, especially in males. The findings on ovarian reserve and failure in women with sickle anaemia have been inconsistent.Aim and objectiveThe aim of this study was to determine and compare the ovarian reserve of Nigerian women with and without sickle cell anaemia attending a University Teaching Hospital.Study DesignThis cross-sectional study was carried out at the Adult Sickle Cell Clinic and the Community Health Clinic of the Lagos University Teaching Hospital.MethodologyA total of 166 participants who met the selection criteria, were recruited for the study. The study population consisted of two groups of women matched for age: 83 women with HbSS and 83 women with HbAA. The haemoglobin phenotype of each participant was determined on alkaline electrophoresis (pH 8.4) before analysis. Serum Anti-Mullerian Hormone (AMH) was determined using Enzyme-linked immunosorbent assay (ELISA) method (Calbiotech Inc. USA, Catalog no AM448T).ResultsThe mean ± SD of serum AMH level in women with HbSS was 3.64 ± 0.65 ng/mL and was lower than that of women with HbAA 7.35 ±1.19 ng/mL (p < 0.001). Serum AMH negatively correlated with age in both study groups (HbAA and HbSS). Also, a significant negative correlation was found between serum AMH and BMI in women with HbAA.ConclusionThe study showed diminished ovarian reserve in women with HbSS when compared to age-matched women with HbAA.

Highlights

Sickle cell disease is the most common monogenetic disorder worldwide
Serum Anti-Mullerian Hormone (AMH) negatively correlated with age in both study groups (HbAA and haemoglobin SS (HbSS))
A significant negative correlation was found between serum AMH and body mass index (BMI) in women with Haemoglobin AA (HbAA)

Summary

Introduction

Sickle cell disease is the most common monogenetic disorder worldwide. The findings on ovarian reserve and failure in women with sickle anaemia have been inconsistent. Sickle cell disease (SCD) is an inherited autosomal recessive haemoglobinopathy characterized by chronic haemolytic anaemia [1, 2]. Sickle cell anaemia (SCA), known as HbSS, is the most common and most severe form of SCD [4]. The prevalence of sickle cell disease ranges between 10% to 45% in various parts of sub-Saharan Africa [5, 6]. Over 300,000 children are born annually with SCD and about 70% of the births occur in sub-Saharan Africa [7].

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