Ovarian Immature Teratoma Detected During Pregnancy

Abstract

Objective: Malignant ovarian immature teratomas should be considered in differantial diagnosis of adnexal masses detected during pregnancy. This paper is reviewing the clinicopathologic and prognostic characteristics and therapeutic options for treatment of immature teratoma during pregnancy in the context of a case of pregnancy complicated with immature teratoma. Materials and Methods: A PubMed and Scopus search was conducted with the key words ‘ovarian immature teratoma’ and ‘pregnancy’ and all related published articles assessed. A total of 24 cases, included our case were included in the study. Age at presentation, clinical findings, histologic grades and stages, treatment options and the prognosis of both mothers and fetuses was analysed. Results: The median age of the patients in the published reports was 27.0± 4.2 ( range 21-36) years. The main presenting symptom was adnexal mass followed by abdominal or pelvic pain. Chemotherapy was added to the surgical treatment in 68.2% of the patients; a Bleomycin, Etoposide and Cisplatin protocol was the preferred treatment option. Prognosis for both mother and fetus were good. Conclusion: Immature teratoma during pregnancy should be treated immediately with surgery ± chemotherapy especially in high grade patients.